Article
Development of a DNA chip for the diagnosis of the most common corneal dystrophies caused by mutations in the betaigh3 gene.
The British journal of ophthalmology - 1 Jun 2007
Yoo So Young, Kim Tae-Im, Lee Sang Yup, Kim Eung Kweon, Keum Ki Chang, Yoo Nae Choon, Yoo Won Min
Abstract excerpt
AIM: To develop a diagnostic DNA chip to detect mutations in the betaigh3 gene causing the most common corneal dystrophies (CDs). METHODS: Samples from 98 people, including patients with betaigh3-associated CDs (beta-aCDs), were examined. Specific primer and probe sets were designed to examine exons 4 and 12 of the betaigh3 gene, in order to identify mutant and wild-type alleles. Mutations were then identified by...
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