Article
Gene Expression Profile of Metastatic Human Pancreatic Cancer Cells Depends on the Organ Microenvironment
1 Jan 2007
Abstract excerpt
To determine the influence of the microenvironment on changes in gene expression, we did microarray analysis on three variant lines of a human pancreatic cancer (FG, L3.3, and L3.6pl) with different metastatic potentials. The variant lines were grown in tissue culture in the subcutis (ectopic) or pancreas (orthotopic) of nude mice. Compared with tissue culture, the number of genes of which the expression was...
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