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Article

Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice.

Human molecular genetics - 15 Feb 2007

Dell'agnello Carlotta, Leo Sara, Agostino Alessandro, Szabadkai György, Tiveron Cecilia, Zulian Alessandra, Prelle Alessandro, Roubertoux Pierre, Rizzuto Rosario, Zeviani Massimo

Abstract excerpt

Leigh syndrome associated with cytochrome c oxidase (COX) deficiency is a mitochondrial disorder usually caused by mutations of SURF1, a gene encoding a putative COX assembly factor. We present here a Surf1-/- recombinant mouse obtained by inserting a loxP sequence in the open reading frame of th...

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Source

Identifiers

PMID: 17210671
DOI: 10.1093/hmg/ddl477

Genes

SURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17210671-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice.PMID 17210671Read ↗

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