Hb F-Charlotte, an A gamma variant with a threonine residue in position gamma 75 and a glycine residue in position gamma 136.

doi:10.3109/03630269009046970

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Article

Hb F-Charlotte, an A gamma variant with a threonine residue in position gamma 75 and a glycine residue in position gamma 136.

Hemoglobin - 1 Jan 1990

Plaseska D, Kutlar F, Wilson J B, Fei Y J, Huisman T H

Abstract excerpt

Structural analyses of an abnormal gamma chain, present in a relative amount of approximately 10% in a cord blood sample of a Black newborn baby, identified two substitutions (gamma 75 Ile----Thr and gamma 136 Ala----Gly) in an apparent variant of the A gamma chain. Gene mapping analysis of genom...

Topics

Base Sequence
Chromosome Mapping
Codon
Fetal Hemoglobin
Glycine
Hemoglobins, Abnormal
Humans
Infant, Newborn
Molecular Sequence Data
Mutation
Threonine

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