Hb J-Anatolia [alpha 61(E10)Lys----Thr]: structural characterization and gene localization of a new alpha chain variant.

doi:10.3109/03630269009046953

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Article

Hb J-Anatolia [alpha 61(E10)Lys----Thr]: structural characterization and gene localization of a new alpha chain variant.

Hemoglobin - 1 Jan 1990

Giordano P C, Fodde R, Amons R, Ploem J E, Bernini L F

Abstract excerpt

We report the characterization of a new hemoglobin variant having a single amino acid substitution (Lys----Thr) at position 61 of the alpha chain. In addition to the structural analysis, we also describe the strategy used for the identification of the base substitution and the localization of the...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Mapping
DNA
Female
Globins
Hemoglobin J
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Hybridization
Oligonucleotide Probes
Polymerase Chain Reaction
Pregnancy

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