Article
Psoriasis: genetic associations and immune system changes.
Genes and immunity - 1 Jan 2007
Liu Y, Krueger J G, Bowcock A M
Abstract excerpt
Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. Psoriasis is currently thought of as a T-cell mediated 'Type-1' autoimmune disease. Gene expression changes in psoriasis lesions have been well documented, and strongly support an important role for tumor necrosis factor and interferon gamma signal...
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