The linkage of Hb Valletta [alpha 2 beta 287(f3)Thr----Pro] and Hb F-Malta-I [alpha 2G gamma 2117(G19)His----Arg] in the Maltese population.

doi:10.1007/BF00201546

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Article

The linkage of Hb Valletta [alpha 2 beta 287(f3)Thr----Pro] and Hb F-Malta-I [alpha 2G gamma 2117(G19)His----Arg] in the Maltese population.

Human genetics - 1 Apr 1991

Kutlar F, Felice A E, Grech J L, Bannister W H, Kutlar A, Wilson J B, Webber B B, Hu H Y, Huisman T H

Abstract excerpt

We have identified a new stable abnormal hemoglobin called Hb Valletta, which is characterized by a Thr----Pro substitution at position 87 of the beta chain. This mutation was found to be linked to that of the gamma chain variant Hb F-Malta-I with a His----Arg mutation at position 117 of the G gamma chain. Both variants were detected in the blood samples of 34 Maltese and two Italian newborn babies with...

Topics

Adult
Amino Acid Sequence
Base Sequence
Chromatography, High Pressure Liquid
DNA
Fetal Hemoglobin
Genetic Linkage
Globins
Hemoglobins, Abnormal
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Isoelectric Focusing

Italy

Malta

Molecular Sequence Data

Mutation

Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 1709134
DOI: 10.1007/BF00201546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1709134-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The linkage of Hb Valletta [alpha 2 beta 287(f3)Thr----Pro] and Hb F-Malta-I [alpha 2G gamma 2117(G19)His----Arg] in the Maltese population.PMID 1709134Read ↗

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