Article
Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction.
Journal of human genetics - 1 Jan 2006
Ishii Nobuaki, Ozaki Kouichi, Sato Hiroshi, Mizuno Hiroya, Susumu Saito, Takahashi Atsushi, Miyamoto Yoshinari, Ikegawa Shiro, Kamatani Naoyuki, Hori Masatsugu, Satoshi Saito, Nakamura Yusuke, Tanaka Toshihiro
Abstract excerpt
Through a large-scale case-control association study using 52,608 haplotype-based single nucleotide polymorphism (SNP) markers, we identified a susceptible locus for myocardial infarction (MI) on chromosome 22q12.1. Following linkage disequilibrium (LD) mapping, haplotype analyses revealed that six SNPs in this locus, all of which were in complete LD, showed markedly significant association with MI (chi2=25.27,...
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