Article
Reaction time of the Continuous Performance Test is an endophenotypic marker for schizophrenia: a study of first-episode neuroleptic-naive schizophrenia, their non-psychotic first-degree relatives and healthy population controls.
Schizophrenia research - 1 Jan 2007
Wang Qiang, Chan Raymond, Sun Jinhua, Yao Jing, Deng Wei, Sun Xueli, Liu Xiehe, Sham Pak C, Ma Xiaohong, Meng Huaqing, Murray Robin M, Collier David A, Li Tao
Abstract excerpt
Sustained attention has been proposed as an endophenotype of schizophrenia, and consequently may be useful as a quantitative trait in genetic studies. In the present study, we used the continuous performance test (CPT) to measure sustained attention in 112 first-episode and neuroleptic-naive schizophrenic patients, 296 of their non-psychotic first-degree relatives, and 452 normal controls. Compared with controls,...
Topics
- Adolescent
- Adult
- Attention
- Female
- Genetic Markers
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Phenotype