Article
High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile.
The Journal of antimicrobial chemotherapy - 1 Dec 2006
Drudy Denise, Quinn Teresa, O'Mahony Rebecca, Kyne Lorraine, O'Gaora Peadar, Fanning Séamus
Abstract excerpt
OBJECTIVES: To determine the mechanism of high-level resistance to fluoroquinolone antimicrobials in toxin-A-negative, toxin-B-positive (A- B+) Clostridium difficile isolates. METHODS: Following culture 16-23S PCR ribotyping was used to determine genomic relationships between A- B+ C. difficile i...
Topics
- Amino Acid Substitution
- Anti-Bacterial Agents
- Aza Compounds
- Bacterial Proteins
- Bacterial Toxins
- Clostridioides difficile
- DNA Gyrase
- DNA, Bacterial
- Dipeptides
- Drug Resistance, Bacterial
- Enterotoxins
- Enzyme Inhibitors
- Fluoroquinolones
- Gatifloxacin