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Article

Clevudine: a potent inhibitor of hepatitis B virus<i>in vitro</i>and<i>in vivo</i>

1 Aug 2006

Abstract excerpt

Clevudine (CLV) is a nucleoside analog of the unnatural L-configuration that has potent anti-hepatitis B virus (HBV) activity in vitro and in vivo with a favorable toxicity profile in all species tested. In cell culture, CLV is readily phosphorylated to the corresponding 5'-triphosphate form of the compound. The mechanism of action of CLV involves the inhibition of the HBV polymerase by CLV 5'-triphosphate. In...

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PMID: 17009935
DOI: 10.1586/14787210.4.4.549

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