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Article

No effect of folic acid and methionine supplementation on D4Z4 methylation in patients with facioscapulohumeral muscular dystrophy.

Neuromuscular disorders : NMD - 1 Nov 2006

van der Kooi E L, de Greef J C, Wohlgemuth M, Frants R R, van Asseldonk R J G P, Blom H J, van Engelen B G M, van der Maarel S M, Padberg G W

Abstract excerpt

Facioscapulohumeral muscular dystrophy (FSHD) is associated with a contraction of the D4Z4 allele on chromosome 4qter. There is also marked DNA hypomethylation of the D4Z4 allele. The DNA hypomethylation may have a central role in the pathogenesis of FSHD. Supplemental folic acid can boost DNA me...

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Identifiers

PMID: 17005397
DOI: 10.1016/j.nmd.2006.08.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17005397-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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No effect of folic acid and methionine supplementation on D4Z4 methylation in patients with facioscapulohumeral muscular dystrophy.PMID 17005397Read ↗

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