Article
Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes.
Diabetes - 1 Oct 2006
Soccio Teresa, Zhang Yuan-Yuan, Bacci Simonetta, Mlynarski Wojciech, Placha Grzegorz, Raggio Greer, Di Paola Rosa, Marucci Antonella, Johnstone Michael T, Gervino Ernest V, Abumrad Nada A, Klein Samuel, Trischitta Vincenzo, Doria Alessandro
Abstract excerpt
Adiponectin, an adipokine facilitating insulin action, has antiatherogenic effects. This study investigated whether common polymorphisms in the adiponectin receptor 1 (ADIPOR1) gene mediating these effects influence the risk of coronary artery disease (CAD) in type 2 diabetes. Linkage disequilibrium analysis of 28 single nucleotide polymorphisms (SNPs) spanning the entire ADIPOR1 locus revealed two haplotype...
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