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Article

The FliN-FliH interaction mediates localization of flagellar export ATPase FliI to the C ring complex.

Biochemistry - 3 Oct 2006

McMurry Jonathan L, Murphy James W, González-Pedrajo Bertha

Abstract excerpt

FliH regulates the flagellar export ATPase FliI, preventing nonproductive ATP hydrolysis. FliH has been shown to stably associate with the C ring protein FliN. Analysis of this complex reveals that FliH is required for FliI localization to the C ring, and thus FliH not only inhibits FliI ATPase activity but also may act to target FliI to the basal body. Quantitative binding studies revealed a KD of 110 nM for...

Topics

Adenosine Triphosphate
Bacterial Proteins
Cell Membrane
Flagella
Hot Temperature
Multiprotein Complexes
Mutation
Protein Binding
Protein Structure, Tertiary
Protein Transport
Proton-Translocating ATPases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella enterica

Source

Identifiers

PMID: 17002279
DOI: 10.1021/bi0605890

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The FliN-FliH interaction mediates localization of flagellar export ATPase FliI to the C ring complex.PMID 17002279Read ↗

Interaction between FliJ and FlhA, components of the bacterial flagellar type III export apparatus.Semantic proximity Read ↗

Assembly dynamics and the roles of FliI ATPase of the bacterial flagellar export apparatus.Semantic proximity Read ↗

FliH, a soluble component of the type III flagellar export apparatus of Salmonella, forms a complex with FliI and inhibits its ATPase activity.Semantic proximity Read ↗

Intrinsic membrane targeting of the flagellar export ATPase FliI: interaction with acidic phospholipids and FliH.Semantic proximity Read ↗

Interaction of FliK with the bacterial flagellar hook is required for efficient export specificity switching.Semantic proximity Read ↗

Mutational analysis of the flagellar rotor protein FliN: identification of surfaces important for flagellar assembly and switching.Semantic proximity Read ↗

Novel insights into the mechanism of well-ordered assembly of bacterial flagellar proteins in Salmonella.Semantic proximity Read ↗

Molecular Basis of the Interaction between the Flagellar Export Proteins FliI and FliH from Helicobacter pyloriSemantic proximity Read ↗

Genetic characterization of conserved charged residues in the bacterial flagellar type III export protein FlhA.Semantic proximity Read ↗

Weak Interactions between Salmonella enterica FlhB and Other Flagellar Export Apparatus Proteins Govern Type III Secretion Dynamics.Semantic proximity Read ↗

Flagellar formation in C-ring-defective mutants by overproduction of FliI, the ATPase specific for flagellar type III secretion.Semantic proximity Read ↗

Interaction of the extreme N-terminal region of FliH with FlhA is required for efficient bacterial flagellar protein export.Semantic proximity Read ↗

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