Article
Genomic organization and allelic expression of UBE3A in chicken.
Gene - 15 Nov 2006
Colosi Dan C, Martin Danielle, Moré Karen, Lalande Marc
Abstract excerpt
UBE3A, the gene associated with Angelman syndrome, is part of a cluster of genes in the human chromosome 15q11-q13/mouse chromosome 7C region, that is subject to genomic imprinting. In human and mouse brain, UBE3A is expressed predominantly from the maternal allele, and the paternal allele is silenced. A current model concerning the evolution of genomic imprinting, the parental conflict hypothesis, posits that...
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