Article
Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium.
Blood - 15 Jan 2007
Yano Kiichiro, Gale Daniel, Massberg Steffen, Cheruvu Pavan K, Monahan-Earley Rita, Morgan Ellen S, Haig David, von Andrian Ulrich H, Dvorak Ann M, Aird William C
Abstract excerpt
Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have...
Topics
- Animals
- Aorta
- Biological Evolution
- Capillaries
- Cell Adhesion
- Dermis
- Endothelium
- Hagfishes
- Heart
- Lectins
- Leukocytes
- Liver