A new monoclonal antibody (CH-F42) recognizes a CD7- subset of normal T lymphocytes and circulating malignant cells in adult T-cell lymphoma-leukemia and Sézary syndrome.

Article

A new monoclonal antibody (CH-F42) recognizes a CD7- subset of normal T lymphocytes and circulating malignant cells in adult T-cell lymphoma-leukemia and Sézary syndrome.

Blood - 1 Oct 1990

Labastide W B, Rana M T, Barker C R

Abstract excerpt

We describe a new rat immunoglobulin M monoclonal antibody (CH-F42) that recognizes a subset (1.5% to 8%) of normal peripheral blood T lymphocytes. The phenotype of these cells was determined, using dual-color immunofluorescence, to be CD2+, CD3+, CD4+, CD5+, CD7-, CD8-. They do not express T-cell activation markers, and are positive for UCHL1 (CD45RO), but negative for 2H4 (CD45RA). The antigen was expressed on...

Topics

Antibodies, Monoclonal
Antigens, CD7
Antigens, Differentiation, T-Lymphocyte
Biomarkers, Tumor
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
Humans
Leukemia-Lymphoma, Adult T-Cell
Microscopy, Electron

Neoplastic Cells, Circulating

Phenotype

Sezary Syndrome

Stem Cells

T-Lymphocyte Subsets

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