Article
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Neoplasia (New York, N.Y.) - 1 Sept 2006
Newton Jessica R, Kelly Kimberly A, Mahmood Umar, Weissleder Ralph, Deutscher Susan L
Abstract excerpt
There is an increasing medical need to detect and spatially localize early and aggressive forms of prostate cancer. Affinity ligands derived from bacteriophage (phage) library screens can be developed to molecularly target prostate cancer with fluorochromes for optical imaging. Toward this goal, we used in vivo phage display and a newly described micropanning assay to select for phage that extravasate and bind...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.