Partial trisomy 18 with minimal anomalies: lack of correspondence between phenotypic manifestations and triplicated loci along chromosome 18.

Abstract excerpt

A 2-year-old boy with microcephaly, developmental delay, and minimal anomalies was found to have an extra submetacentric chromosome equivalent to 18pter----q12. Review of the phenotypes produced by various triplicated 18 regions supports the hypothesis that no one chromosome 18 region is sufficient to produce the phenotype of trisomy 18. The mild phenotype of trisomy 18p, the variable phenotype of trisomy...

Topics

• Child, Preschool
• Chromosomes, Human, Pair 18
• Developmental Disabilities
• Humans
• Karyotyping
• Male
• Microcephaly
• Phenotype
• Trisomy