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Article

Eukaryotic cyclophilin as a molecular switch for effector activation.

Molecular microbiology - 1 Sept 2006

Coaker Gitta, Zhu George, Ding Zhaofeng, Van Doren Steven R, Staskawicz Brian

Abstract excerpt

Gram-negative phytopathogenic bacteria, such as Pseudomonas syringae, deliver multiple effector proteins into plant cells during infection. It is hypothesized that certain plant and mammalian effector proteins need to traverse the type III secretion system unfolded and are delivered into host cells as inactive enzymes. We have previously identified cyclophilin as the Arabidopsis eukaryotic activator of AvrRpt2, a...

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Identifiers

PMID: 16968222
DOI: 10.1111/j.1365-2958.2006.05335.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Eukaryotic cyclophilin as a molecular switch for effector activation.PMID 16968222Read ↗

Activation of a phytopathogenic bacterial effector protein by a eukaryotic cyclophilin.Semantic proximity Read ↗

The targeting of plant cellular systems by injected type III effector proteins.Semantic proximity Read ↗

Distinct regions of the Pseudomonas syringae coiled-coil effector AvrRps4 are required for activation of immunity.Semantic proximity Read ↗

Cyclophilin A Binds to the Viral RNA and Replication Proteins, Resulting in Inhibition of Tombusviral Replicase AssemblySemantic proximity Read ↗

TAL effectors target the C-terminal domain of RNA polymerase II (CTD) by inhibiting the prolyl-isomerase activity of a CTD-associated cyclophilin.Semantic proximity Read ↗

Cleavage of the Pseudomonas syringae type III effector AvrRpt2 requires a host factor(s) common among eukaryotes and is important for AvrRpt2 localization in the host cell.Semantic proximity Read ↗

Mapping ortholog-restricted ligandable cysteines in the wheat pathogen <i>Zymoseptoria tritici</i>Semantic proximity Read ↗

Immunophilins and Parvulins. Superfamily of Peptidyl Prolyl Isomerases in ArabidopsisSemantic proximity Read ↗

Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1.Semantic proximity Read ↗

Mutations in a new Arabidopsis cyclophilin disrupt its interaction with protein phosphatase 2A.Semantic proximity Read ↗

The Pseudomonas syringae type III effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis auxin/indole acetic acid protein turnover.Semantic proximity Read ↗

Cyclotide biosynthesis.Semantic proximity Read ↗

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