Article
Synergistic effect of interleukin-6 promoter (IL6 -634C/G) and intercellular adhesion molecule-1 (ICAM-1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Oct 2006
Kitawaki Jo, Kiyomizu Miyo, Obayashi Hiroshi, Ohta Mitsuhiro, Ishihara Hiroaki, Hasegawa Goji, Nakamura Naoto, Yoshikawa Toshikazu, Honjo Hideo
Abstract excerpt
PROBLEM: Endometriosis is an immune-related, chronic inflammatory disease with a polygenic predisposition. The aim of this study was to investigate whether the interleukin-6 (IL-6) gene promoter region polymorphism (-634C/G) and the intercellular adhesion molecule-1 (ICAM-1) gene 469K/E polymorphism are responsible in part for the genetic susceptibility to endometriosis. METHODS OF STUDY: The IL-6 -634C/G and...
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