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Article

SMN1 gene, but not SMN2, is a risk factor for sporadic ALS.

Neurology - 10 Oct 2006

Corcia P, Camu W, Halimi J-M, Vourc'h P, Antar C, Vedrine S, Giraudeau B, de Toffol B, Andres C R

Abstract excerpt

BACKGROUND: SMN1 gene deletions cause spinal muscular atrophy, and SMN2 gene deletions have been associated with sporadic lower motor neuron diseases. OBJECTIVES: To study the frequency of abnormal SMN1 gene copy numbers and to determine whether SMN2 gene modulates the risk of amyotrophic lateral sclerosis (ALS) or the duration of evolution. METHOD: The authors studied SMN1 and SMN2 genes in 600 patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16931506
DOI: 10.1212/01.wnl.0000233830.85206.1e

Genes

SMN1
SMN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SMN1 gene, but not SMN2, is a risk factor for sporadic ALS.PMID 16931506Read ↗

Abnormal SMN1 gene copy number is a susceptibility factor for amyotrophic lateral sclerosis.Semantic proximity Read ↗

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SMN1 duplications contribute to sporadic amyotrophic lateral sclerosis susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

SMN1 gene duplications are associated with sporadic ALS.Semantic proximity Read ↗

SMN genotypes producing less SMN protein increase susceptibility to and severity of sporadic ALS.Semantic proximity Read ↗

SMN1 gene duplications are more frequent in patients with progressive muscular atrophy.Semantic proximity Read ↗

Association between the SMN2 gene copy number and clinical characteristics of patients with spinal muscular atrophy with homozygous deletion of exon 7 of the SMN1 gene.Semantic proximity Read ↗

Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2.Semantic proximity Read ↗

Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy.Semantic proximity Read ↗

Homozygous SMN1 deletions in unaffected family members and modification of the phenotype by SMN2.Semantic proximity Read ↗

Robust quantification of the SMN gene copy number by real-time TaqMan PCR.Semantic proximity Read ↗

Correlation between SMA type and SMN2 copy number revisited: An analysis of 625 unrelated Spanish patients and a compilation of 2834 reported cases.Semantic proximity Read ↗

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