Article
Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Sept 2006
Ferrara Felicetto, Palmieri Salvatore, Pollio Filiberto, Lo Pardo Catia, Graziano Daniela, Celentano Maria, D'Amico Maria Rosaria, Vicari Laura, Izzo Barbara, Pane Fabrizio
Abstract excerpt
Fetal liver tyrosine kinase 3 (FLT3) mutations represent a powerful prognostic indicator in acute myeloid leukemia (AML). Further, interaction between FLT3 and its ligand plays a role in normal hematopoiesis. Accordingly, FLT3 mutations may affect mobilization of peripheral blood stem cells (PBSCs) and feasibility of autologous stem cell transplantation (ASCT) in AML. We analyzed the effect of FLT3 mutations on...
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