Article
Induction of squamous cell carcinoma of forestomach in diabetic rats by single alloxan treatment.
Cancer science - 1 Oct 2006
Kodama Yasushi, Ozaki Kiyokazu, Sano Tomoya, Matsuura Tetsuro, Akagi Hiroyuki, Narama Isao
Abstract excerpt
Male rats of WBN/Kob strain are one of the diabetic model animals and develop long-lasting diabetic symptoms and some complications from about 40 weeks of age without any treatment. A single intravenous dose of alloxan, a non-genotoxic diabetogenic chemical, frequently induced proliferative lesions of squamous epithelium in tongue, esophagus and forestomach of male and female WBN/Kob rats, and hastened the onset...
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