Article
WT1 mutations in nephrotic syndrome revisited. High prevalence in young girls, associations and renal phenotypes.
Pediatric nephrology (Berlin, Germany) - 1 Oct 2006
Aucella Filippo, Bisceglia Luigi, De Bonis Patrizia, Gigante Maddalena, Caridi Gianluca, Barbano Giancarlo, Mattioli Gerolamo, Perfumo Francesco, Gesualdo Loreto, Ghiggeri Gian Marco
Abstract excerpt
WT1 mutations have been considered a rare cause of nephrotic syndrome but recent reports challenge this assumption. Exclusion of inherited forms is a basic point in any therapeutic strategy to nephrotic syndrome since they do not respond to drugs. We screened for WT1 mutations in 200 patients with nephrotic syndrome: 114 with steroid resistance (SRNS) and 86 with steroid dependence (SDNS) for whom other inherited...
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