Article
Hypocapnia induces caspase-3 activation and increases Abeta production.
Neuro-degenerative diseases - 1 Jan 2004
Xie Zhongcong, Moir Robert D, Romano Donna M, Tesco Giuseppina, Kovacs Dora M, Tanzi Rudolph E
Abstract excerpt
BACKGROUND: At least half of all cases of early onset (<60) familial Alzheimer's disease (FAD) are caused by any of over 150 mutations in three genes: the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2). Mutant forms of PS1 have been shown to sensitize cells to apoptot...
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