Article
An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival.
Genome research - 1 Sept 2006
Fyfe John C, Menotti-Raymond Marilyn, David Victor A, Brichta Lars, Schäffer Alejandro A, Agarwala Richa, Murphy William J, Wedemeyer William J, Gregory Brittany L, Buzzell Bethany G, Drummond Meghan C, Wirth Brunhilde, O'Brien Stephen J
Abstract excerpt
The leading genetic cause of infant mortality is spinal muscular atrophy (SMA), a clinically and genetically heterogeneous group of disorders. Previously we described a domestic cat model of autosomal recessive, juvenile-onset SMA similar to human SMA type III. Here we report results of a whole-g...
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