Giant cells: contradiction to two-hit model of tuber formation?

Abstract excerpt

Tuberous sclerosis (TSC) is an autosomal dominant disease characterized by the formation of hamartomatous lesions in many organs, including brain, heart or kidneys. It has been found that TSC is caused by the mutation in one of the two tumor suppressor genes: TSC1 or TSC2, encoding hamartin and tuberin, respectively. According to Knudson's two-hit model of tumorigenesis, second-hit mutation and resulting loss of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to TSC1 gene
• Share to Giant Cells
• Share to Loss of Heterozygosity