Article
CombiMatrix oligonucleotide arrays: genotyping and gene expression assays employing electrochemical detection.
Biosensors & bioelectronics - 15 Apr 2007
Ghindilis Andrey L, Smith Maria W, Schwarzkopf Kevin R, Roth Kristian M, Peyvan Kia, Munro Sandra B, Lodes Michael J, Stöver Axel G, Bernards Karen, Dill Kilian, McShea Andy
Abstract excerpt
Electrochemical detection has been developed and assay performances studied for the CombiMatrix oligonucleotide microarray platform that contains 12,544 individually addressable microelectrodes (features) in a semiconductor matrix. The approach is based on the detection of redox active chemistries (such as horseradish peroxidase (HRP) and the associated substrate TMB) proximal to specific microarray electrodes....
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