Article
Localization of a mutant gene for cleft palate and ankyloglossia in an X-linked Icelandic family.
Journal of craniofacial genetics and developmental biology - 1 Jan 2000
Moore G E, Williamson R, Jensson O, Chambers J, Takakubo F, Newton R, Balacs M A, Ivens A
Abstract excerpt
Common congenital malformations such as cleft lip and cleft palate are in most cases multifactorial in origin, involving both environmental and genetic components. Molecular biology techniques have enabled the successful chromosomal localization of many mutant genes from disorders that exhibit simple Mendelian segregation, whether autosomally dominant (e.g., Huntington's disease), autosomal recessive (e.g.,...
Topics
- Cleft Palate
- Female
- Genetic Linkage
- Humans
- Lod Score
- Male
- Mutation
- Polymorphism, Restriction Fragment Length
- Restriction Mapping
- Tongue
- X Chromosome