Genetic control of immune response and disease susceptibility by the HLA-DQ gene.

doi:10.1016/0923-2494(91)90048-n

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Article

Genetic control of immune response and disease susceptibility by the HLA-DQ gene.

Research in immunology - 1 Jan 2000

Nishimura Y, Kamikawaji N, Fujisawa K, Yoshizumi H, Yasunami M, Kimura A, Sasazuki T

Abstract excerpt

The particular alleles of the HLA-DQ locus may control the low immune response to natural antigens by a dominant genetic trait through the immune suppression mediated by CD8+ suppressor T cells. The suppressor T cells may be activated by DQ-restricted and antigen-specific CD4+ suppressor/inducer T cells, because (1) a statistically significant association and linkage between low immune responsiveness to the...

Topics

Autoantigens
Autoimmune Diseases
Bacterial Proteins
CD4-Positive T-Lymphocytes
Disease Susceptibility
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens
Humans
Streptococcus
T-Lymphocytes

T-Lymphocytes, Helper-Inducer

T-Lymphocytes, Regulatory

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