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Article

Synthesis and characterization of NBD-PS: a fluorescent analog of cerebroside arylsulfatase A deficiency disorders.

Molecular and chemical neuropathology - 1 Apr 1991

Louis A I, Widen K E, Tsay K K, Fluharty A L

Abstract excerpt

N-[7-Nitrobenz-2-oxa-1,3-diazol-4-yl]psychosine sulfate (NBD-PS), a fluorescent analog of cerebroside sulfate (CS), was synthesized and tested as an alternative to the radiolabeled forms of CS used for assaying arylsulfatase A (ASA) in its physiological role as a cerebroside sulfate sulfohydrolase. NBD-PS simulates the natural substrate for ASA. Protocols have been developed for its use in differentiating low...

Topics

4-Chloro-7-nitrobenzofurazan
Animals
Cerebroside-Sulfatase
Cerebrosides
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Fluorescent Dyes
Genotype
Humans
Phenotype
Phosphatidylserines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Spectrometry, Fluorescence

Sulfur Radioisotopes

Source

Identifiers

PMID: 1680331
DOI: 10.1007/BF03159931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1680331-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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