Article
No VSX1 gene mutations associated with keratoconus.
Investigative ophthalmology & visual science - 1 Jul 2006
Aldave Anthony J, Yellore Vivek S, Salem Andrew K, Yoo Gina L, Rayner Sylvia A, Yang Huiying, Tang George Y, Piconell Yoana, Rabinowitz Yaron S
Abstract excerpt
PURPOSE: To determine whether mutations of the VSX1 gene play a pathogenetic role in the development of keratoconus (KTCN). METHODS: DNA extraction, PCR amplification, and direct sequencing of the VSX1 gene were performed in 100 unrelated patients with diagnoses of clinical and topographic features of KTCN. RESULTS: Of the four previously identified presumed pathogenic mutations in the VSX1 gene (Leu17Pro,...
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