Article
Genetic determinants of bone mass do not relate with breast cancer risk in US white and African-American women.
Breast cancer research and treatment - 1 Nov 2006
VandeVord Pamela J, Wooley Paul H, Darga Linda L, Severson Richard K, Wu Bin, Nelson Dorothy A
Abstract excerpt
INTRODUCTION: The association between high bone mass and increased breast cancer risk has been established. Identification of polymorphisms and the resultant variant receptors suggests the possibility of differential effects on hormone responsive genes when complexed with the hormones. Both estrogen receptor-alpha (ER) and vitamin D receptor (VDR) polymorphisms have been associated with bone density. Thus, we...
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