Article
Endothelin-1, vascular endothelial growth factor and systolic pulmonary artery pressure in patients with Chuvash polycythemia.
Haematologica - 1 Jun 2006
Bushuev Vladimir I, Miasnikova Galina Y, Sergueeva Adelina I, Polyakova Lydia A, Okhotin Daniel, Gaskin Peter R, Debebe Zufan, Nekhai Sergei, Castro Oswaldo L, Prchal Josef T, Gordeuk Victor R
Abstract excerpt
BACKGROUND AND OBJECTIVES: Endothelin-1 has been associated with development of hypoxia-related pulmonary hypertension and vascular endothelial growth factor (VEGF) with protection from this complication. In Chuvash polycythemia, homozygous germline von Hippel-Lindau (VHL) 598C->T leads to up-regulation during normoxia of hypoxia inducible factor-1a and several hypoxia-controlled genes including erythropoietin...
Topics
- Altitude
- Electrocardiography
- Endothelin-1
- Humans
- Hypertension, Pulmonary
- Hypoxia
- Mutation
- Polycythemia
- Polymorphism, Single Nucleotide
- Pulmonary Artery