Article
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.
Journal of medical genetics - 1 Nov 2006
Seal J L, Gornick M C, Gogtay N, Shaw P, Greenstein D K, Coffey M, Gochman P A, Stromberg T, Chen Z, Merriman B, Nelson S F, Brooks J, Arepalli S, Wavrant-De Vrièze F, Hardy J, Rapoport J L, Addington A M
Abstract excerpt
Schizophrenia is a severe mental disorder affecting approximately 1% of the world's population. Although the aetiology of schizophrenia is complex and multifactorial, with estimated heritabilities as high as 80%, genetic factors are the most compelling. Childhood-onset schizophrenia (COS), defined as onset of schizophrenia before the age of 13 years, is a rare and malignant form of the illness that may have more...
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