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<i>Anopheles gambiae</i> P450 reductase is highly expressed in oenocytes and <i>in vivo</i> knockdown increases permethrin susceptibility

31 May 2006

Abstract excerpt

We describe an in vivo model for investigation of detoxification mechanisms of the mosquito Anopheles gambiae, important for the development of malaria control programmes. Cytochrome P450s are involved in metabolic insecticide resistance and require NADPH cytochrome P450 reductase (CPR) to function. Here we demonstrate that the major sites of adult mosquito CPR expression are oenocytes, mid-gut epithelia and head...

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PMID: 16756551
DOI: 10.1111/j.1365-2583.2006.00647.x

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