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[Mutation analysis of SRD5A2 gene in patients with hypospadias].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery - 1 Mar 2006

Xu Jia-jie, Li Sen-kai, Li Qiang, Fan Ju-feng, Wang Yan-ping, Li Yang-qun, Shen Yan

Abstract excerpt

OBJECTIVE: To explore possible molecular mechanism of hypospadias and relationship of the mutation of SRD5A2 gene to hypospadias. METHODS: 96 blood samples from the patients with hypospadias were obtained and DNA was extracted from blood leukocytes. Polymerase chain reaction and direct sequencing were performed to analyze the coding regions of SRD5A2 gene. RESULTS: 8 mutations were detected from 14 cases,...

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PMID: 16736621

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