DNA amplification for DQ typing as an adjunct to serological prenatal HLA typing for the identification of potential donors for umbilical cord blood transplantation.

doi:10.1016/0198-8859(91)90070-p

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DNA amplification for DQ typing as an adjunct to serological prenatal HLA typing for the identification of potential donors for umbilical cord blood transplantation.

Human immunology - 1 Jan 1991

Pollack M S, Auerbach A D, Broxmeyer H E, Zaafran A, Griffith R L, Erlich H A

Abstract excerpt

It has recently been demonstrated that umbilical cord blood from genotypically human leukocyte antigen (HLA)-matched donors can provide sufficient numbers of progenitor cells for hematopoietic reconstitution. This technique has been successfully applied in the treatment of two children affected with Fanconi anemia (FA). Fetal cells from the potential sibling donors were first tested to determine that the fetus...

Topics

Blood Transfusion
DNA
Fanconi Anemia
Female
Fetal Blood
HLA-DQ Antigens
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Infant, Newborn

Male

Phenotype

Polymerase Chain Reaction

Pregnancy

Prenatal Diagnosis

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