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Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza

22 May 2006

Abstract excerpt

Newcastle disease virus (NDV)-expressing avian influenza virus (AIV) hemagglutinin (HA) of subtype H5 was constructed by reverse genetics. A cloned full-length copy of the genome of the lentogenic NDV strain Clone 30 was used for insertion of the ORF encoding the HA of the highly pathogenic AIV isolate A/chicken/Italy/8/98 (H5N2) in the intergenic region between the NDV fusion and hemagglutinin-neuraminidase (HN)...

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PMID: 16717197
DOI: 10.1073/pnas.0602461103

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