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Article

Recombinant Newcastle Disease Virus as a Vaccine Vector

1 Dec 2001

Abstract excerpt

A complete cDNA clone of the Newcastle disease virus (NDV) vaccine strain Hitchner B1 was constructed, and infectious recombinant virus expressing an influenza virus hemagglutinin was generated by reverse genetics. The rescued virus induces a strong humoral antibody response against influenza virus and provides complete protection against a lethal dose of influenza virus challenge in mice, demonstrating the...

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PMID: 11689668
DOI: 10.1128/jvi.75.23.11868-11873.2001

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