Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis.

doi:10.1016/0140-6736(91)90940-q

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Article

Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis.

Lancet (London, England) - 9 Feb 1991

Dunlop M G, Wyllie A H, Steel C M, Piris J, Evans H J

Abstract excerpt

41 symptom-free individuals aged 0-39 years who were at risk of familial adenomatous polyposis (FAP) were genotyped with six linked DNA probes. 28 individuals were informative for probes flanking the gene and 14 people assigned a probe-derived risk of over 0.93 were subsequently shown to be affected by clinical screening. 4 individuals who had been discharged from follow-up were designated high risk by this...

Topics

Adenomatous Polyposis Coli
Adolescent
Adult
Child
Child, Preschool
DNA Probes
Evaluation Studies as Topic
Female
Genetic Linkage
Genotype
Humans
Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Male

Pedigree

Recombination, Genetic

Retinal Pigments

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 1671230
DOI: 10.1016/0140-6736(91)90940-q

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1671230-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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