Article
Linked DNA markers for presymptomatic diagnosis of familial adenomatous polyposis.
Lancet (London, England) - 9 Feb 1991
Dunlop M G, Wyllie A H, Steel C M, Piris J, Evans H J
Abstract excerpt
41 symptom-free individuals aged 0-39 years who were at risk of familial adenomatous polyposis (FAP) were genotyped with six linked DNA probes. 28 individuals were informative for probes flanking the gene and 14 people assigned a probe-derived risk of over 0.93 were subsequently shown to be affected by clinical screening. 4 individuals who had been discharged from follow-up were designated high risk by this...
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