Article
The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.
Biomaterials - 1 Sept 2006
Uebersax Lorenz, Fedele Denise E, Schumacher Claudia, Kaplan David L, Merkle Hans P, Boison Detlev, Meinel Lorenz
Abstract excerpt
Adenosine kinase deficient (Adk-/-) embryonic stem cells (ESCs) encapsulated in synthetic polymers have previously been shown to provide therapeutic adenosine release and transient seizure suppression in epileptic rats. Here we explored the utility of biopolymer-substrates to promote long-term adenosine release from Adk-/- ESCs. Three different substrates were studied: (1) type I collagen (Col-1), (2)...
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