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Article

Group A Streptococcal Myonecrosis: Increased Vimentin Expression after Skeletal‐Muscle Injury Mediates the Binding ofStreptococcus pyogenes

15 May 2006

Abstract excerpt

Necrotizing fasciitis and myonecrosis caused by invasive infection with group A streptococci (GAS) are life-threatening conditions that have reemerged worldwide. Half of all GAS myonecrosis cases have no known portal of entry; yet, for unknown reasons, infection becomes established precisely at the site of a prior, nonpenetrating minor injury, such as a muscle strain. We hypothesized that GAS establishes...

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PMID: 16703512
DOI: 10.1086/504261

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