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Article

AXR4 is required for localization of the auxin influx facilitator AUX1.

Science (New York, N.Y.) - 26 May 2006

Dharmasiri S, Swarup R, Mockaitis K, Dharmasiri N, Singh S K, Kowalchyk M, Marchant A, Mills S, Sandberg G, Bennett M J, Estelle M

Abstract excerpt

The AUX1 and PIN auxin influx and efflux facilitators are key regulators of root growth and development. For root gravitropism to occur, AUX1 and PIN2 must transport auxin via the lateral root cap to elongating epidermal cells. Genetic studies suggest that AXR4 functions in the same pathway as AUX1. Here we show that AXR4 is a previously unidentified accessory protein of the endoplasmic reticulum (ER) that...

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Identifiers

PMID: 16690816
DOI: 10.1126/science.1122847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

AXR4 is required for localization of the auxin influx facilitator AUX1.PMID 16690816Read ↗

Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter.Semantic proximity Read ↗

The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis.Semantic proximity Read ↗

AtSNX1 defines an endosome for auxin-carrier trafficking in Arabidopsis.Semantic proximity Read ↗

Inter-regulation of the unfolded protein response and auxin signaling.Semantic proximity Read ↗

IAA8 involved in lateral root formation interacts with the TIR1 auxin receptor and ARF transcription factors in Arabidopsis.Semantic proximity Read ↗

Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1.Semantic proximity Read ↗

ERECTA family genes regulate auxin transport in the shoot apical meristem and forming leaf primordia.Semantic proximity Read ↗

Relocalization of the PIN1 auxin efflux facilitator plays a role in phototropic responses.Semantic proximity Read ↗

AUX1 regulates root gravitropism in Arabidopsis by facilitating auxin uptake within root apical tissues.Semantic proximity Read ↗

EIR1, a root-specific protein involved in auxin transport, is required for gravitropism in Arabidopsis thaliana.Semantic proximity Read ↗

The axr4 auxin-resistant mutants of Arabidopsis thaliana define a gene important for root gravitropism and lateral root initiation.Semantic proximity Read ↗

The arabidopsis thaliana AGRAVITROPIC 1 gene encodes a component of the polar-auxin-transport efflux carrier.Semantic proximity Read ↗

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