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Article

Estrogen enhances the efficacy of an oncolytic HSV-1 mutant in the treatment of estrogen receptor-positive breast cancer.

International journal of oncology - 1 Jun 2006

Stiles Brendon M, Adusumilli Prasad S, Stanziale Stephen F, Eisenberg David P, Bhargava Amit, Kim Teresa H, Chan Mei-Ki, Huq Rumana, Gonen Mithat, Fong Yuman

Abstract excerpt

Oncolytic herpes simplex virus-1 (HSV-1) mutants selectively replicate in and lyse tumor cells. Viral replication is dependent on the cellular proliferative mechanism. Estrogen increases cellular proliferation and decreases apoptosis in estrogen receptor-positive (ER+) human breast cancer cells. We hypothesize that the cellular changes produced by estrogen may enhance oncolytic viral replication and improve the...

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Source

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Identifiers

PMID: 16685445
PMCID: PMC1459534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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