Article
Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges.
Hormones (Athens, Greece) - 1 Jan 2000
Körner Antje, Blüher Susann, Kapellen Thomas, Garten Ante, Klammt Jürgen, Kratzsch Jürgen, Kiess Wieland
Abstract excerpt
Body weight is regulated by a feedback loop in which peripheral signals report nutritional information to an integratory center in the brain. The cloning of the ob gene is consistent with this concept and suggests that body fat content in adult rodents is regulated by a negative feedback loop centered in the hypothalamus. In recent years a number of additional signaling molecules secreted by adipose tissue have...
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