Article
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
PLoS pathogens - 1 Mar 2006
Urisman Anatoly, Molinaro Ross J, Fischer Nicole, Plummer Sarah J, Casey Graham, Klein Eric A, Malathi Krishnamurthy, Magi-Galluzzi Cristina, Tubbs Raymond R, Ganem Don, Silverman Robert H, DeRisi Joseph L
Abstract excerpt
Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a viral infection might contribute to prostate cancer in individuals harboring the R462Q variant. A...
Read the complete abstract on PubMedTopics
- Adenocarcinoma
- Amino Acid Sequence
- Biomarkers, Tumor
- DNA, Viral
- Endoribonucleases