Article
Nosocomial spread of an amikacin resistance gene on both a mobilized, nonconjugative plasmid and a conjugative plasmid.
Antimicrobial agents and chemotherapy - 1 Aug 1991
Hopkins J D, Flores A, del Pilar Pla M, Lester S, O'Brien T F
Abstract excerpt
Resistance to amikacin among members of the family Enterobacteriaceae at a hospital in Venezuela rose from 2% in 1979 to 5% in 1984 and 10% in 1985 as amikacin usage rose 20-fold to exceed gentamicin usage. Resistance to gentamicin remained at 25 to 27%. We examined the plasmids from 21 isolates...
Topics
- Alleles
- Amikacin
- Conjugation, Genetic
- Cross Infection
- DNA Transposable Elements
- Drug Resistance, Microbial
- Enterobacteriaceae
- Enterobacteriaceae Infections
- Escherichia coli
- Humans
- Klebsiella pneumoniae
- Operon
- Plasmids