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Article

Co-expression of different subunits of human phenylalanine hydroxylase: evidence of negative interallelic complementation.

Biochimica et biophysica acta - 1 May 2006

Leandro João, Nascimento Cátia, de Almeida Isabel Tavares, Leandro Paula

Abstract excerpt

To study the interaction between two different subunits of the heteromeric human phenylalanine hydroxylase (hPAH), present in hyperphenylalaninemic (HPA) compound heterozygous patients, heteroallelic hPAH enzymes were produced. A dual vector expression system was used (PRO Bacterial Expression System) in which each mutant subunit was expressed from a separate compatible vector, with different epitope tags, in a...

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Source

Identifiers

PMID: 16545551
DOI: 10.1016/j.bbadis.2006.02.001

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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